Hi, Ashwin.
You definetly can deal with any tables in a database, so there's nothing surprising.
You can set "External SAP HANA View" for your DSO and it will generate a corresponding Analytical View in HANA content (regardless of setting for SIDs as of BW SPS10). Then you can consume this view (so consuming DSO's data) in another Calculation View (or any DB object, and also in Composite Provider).
Regards,
Andrey.